Prostate Cancer Advanced Topics: For Clinicians & Researchers
📚 All Advanced Topics
Prostate Anatomy & Histology
Detailed anatomy of the prostate – zones, histology, blood supply, innervation, and embryology. For surgeons and pathologists.
Prostate Cancer Molecular Subtypes
ERG fusion, SPOP mutations, CHD1 loss, and molecular classification of prostate cancer. Clinical implications.
PSMA PET Scan
PSMA PET/CT for staging, biochemical recurrence, and therapy selection. Comparison to conventional imaging.
Biomarkers for Prostate Cancer
PCA3, PHI, 4Kscore, SelectMDx, ExoDx – clinical utility and limitations.
Genetic Syndromes & Prostate Cancer
BRCA1/2, HOXB13, Lynch syndrome, ATM, CHEK2 – hereditary prostate cancer syndromes and testing guidelines.
Prostate Cancer in Transgender Patients
Screening, diagnosis, and treatment considerations for transgender women and non-binary individuals.
BPH Pathophysiology – Updated
Molecular mechanisms of BPH – inflammation, hormones, growth factors, and stem cells.
Prostatitis Classification (NIH)
NIH classification system for prostatitis – Types I-IV, diagnostic criteria, and clinical implications.
Active Surveillance Protocols
PRIAS, Johns Hopkins, UCSF, and other active surveillance protocols – inclusion criteria and follow-up schedules.
Salvage Therapy for Recurrent Prostate Cancer
Salvage radiation, salvage cryotherapy, salvage HIFU, and salvage radical prostatectomy after primary treatment failure.
Prostate Cancer Clinical Trials
Active and recent landmark trials – STAMPEDE, CHAARTED, LATITUDE, TITAN, PROfound, VISION, and others.
Cost-Effectiveness of Prostate Cancer Screening
Economic analysis of PSA screening, MRI, and biomarkers – value-based care considerations.
Artificial Intelligence in Prostate Cancer Diagnosis
AI for MRI interpretation, pathology grading, and risk prediction. Current applications and future directions.
🎯 Who Should Read This Section?
- Urologists and oncologists – Stay updated on advanced topics in prostate cancer diagnosis and treatment.
- Medical students and residents – Build deeper knowledge for exams and clinical practice.
- Researchers – Understand current concepts and identify knowledge gaps.
- Motivated patients – For those who want to understand the science behind their condition.
🔗 Related Pillars
- Pillar 1: Prostate Basics – Anatomy, function, PSA, DRE.
- Pillar 4: Prostate Cancer – Screening, diagnosis, and staging.
- Pillar 5: Prostate Cancer Treatment – Surgery, radiation, hormone therapy.
Disclaimer: This information is for educational purposes and intended for clinicians and researchers. It is not a substitute for clinical judgment. Consult primary literature for treatment decisions.